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Turmeric Studies

"Curcumin (a diferuloylmethane) was found to be the most widely studied compound as evinced by more than 9000 citations in the literature, with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, antidiabetic, antiarthritic, antiatherosclerotic, antidepressant, antiaging, antimicrobial, wound healing and memory-enhancing activities. Moreover, it exerts chemopreventive, chemosensitization and radiosensitization effects as well. In traditional Indian medicine, this spice has been also used to treat different ailments such as gynecological problems, gastric problems, hepatic disorders, infectious diseases, blood disorders, acne, psoriasis, dermatitis, rash and other chronic ailments. Diverse in vivo studies have also indicated its potential against pro-inflammatory diseases, cancers, neurodegenerative diseases, depression, diabetes, obesity and atherosclerosis.  These traits can possibly be attributed to the methoxy, hydroxyl, α, βunsaturated carbonyl moiety or diketone groups present in curcumin. Besides its safety and tolerability, cost-effectiveness is an added advantage of this compound. To date, over 100 different clinical trials have been completed with curcumin, which clearly show its safety, tolerability and its effectiveness against various chronic diseases in humans." - British Journal of Pharmacology

 

"During the last decade, pharmacokinetics, pharmacodynamics and pharmacological properties of curcumin, a yellow-orange polyphenolic compound, have been extensively studied. Significant antitumor, antioxidant, antiviral, lipid-lowering, chemopreventive, hepatoprotective and neuroprotective properties of curcumin have been confirmed. Recent studies have also confirmed the pharmacological activity of curcumin as anti-inflammatory and immunomodulatory agent. It is established that mechanism of anti-inflammatory occurs through the inhibition of cyclooxegenase-2 (COX-2) and lipoxygenases (LOX), and the induction of nitric oxide synthase (iNOS). Also, it is suggested that curcumin inhibits the action of inflammatory cytokines, such as interleukins and chemokines. Due to its pronounced anti-inflammatory activity, curcumin is considered to be a potential mediator of accelerating the healing process of acute and chronic wounds and may inhibit the production of tumor necrosis factor TNF alpha and TNF alpha mediated cellular signalling pathway. Antimicrobial potential of curcumin has been evaluated against a wide range of microorganisms, including both Gram-positive and Gram-negative bacteria as well as the fungi. Curcumin has been described as a promising antifungal of clinical interest with stronger antifungal activity than fluconazole. A recent study has suggested a possible mechanism of antifungal act ivity of curcumin through photodynamic technology and oxidative stress." - Curcumin: Natural Antimicrobial and Anti Inflammatory Agent, Journal of Pharmaceutical Research International | 2021

"We found 12,595 papers on curcumin (1924–2018) and 4738 (1983–2018) of which were on curcumin and cancer; that means 37% of the published papers on curcumin has cancer as the major targeted disease. Curcumin was isolated for the first time in 1815 by two scientists, Vogel and Pelletier, from Harvard College Laboratory. Since then, the scientific interest towards curcumin has increased and, more and more, its health benefits have been discovered. Curcumin belongs to a chemical class of polyphenols; it is known as diferuloylmethane and its IUPAC name is (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, with a chemical formula of C21H20O6 and a molecular weight of 368.38. The chemistry of curcumin is at the basis of its several biological activities. The therapeutic benefits of curcumin have been demonstrated in multiple chronic diseases: inflammation, arthritis, metabolic syndrome, liver disease, obesity, neurodegenerative diseases and, above all, in several cancers." - Nutrients Journal

"Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protection and promotion of human health. In addition to presenting an overview of the gut metabolism of curcumin, this paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, and also intensively discusses its health benefits, including the protective or preventive effects on cancers and diabetes, as well as the liver, nervous system, and cardiovascular systems, highlighting the potential molecular mechanisms. Besides, the beneficial effects of curcumin on human are further stated based on clinical trials." - Nutrients Journal

"7,000 published articles have shed light on the various aspects of curcumin including its antioxidant, hypoglycemic, anti-inflammatory and anti-cancer activities. Oxidative stress and inflammation play a pivotal role in various diseases like diabetes, cancer, arthritis, Alzheimer's disease and cardiovascular diseases." - Food and Chemical Toxicology Journal

"6.000 articles published within the past two decades have discussed the molecular basis for the antioxidant, anti-inflammatory, antibacterial, antiviral, antifungal, and anticancer activities assigned to this nutraceutical. Over sixty five clinical trials conducted on this molecules, have shed light on the role of curcumin in various chronic conditions, including autoimmune, cardiovascular, neurological, and psychological diseases, as well as diabetes and cancer." - Biotechnology Advances Journal

"Curcumin has been used as pharmacological traditional medicinal agent in Ayurvedic medicine for 6000 years. The current review article presents effective role of curcumin against cancer, diabetes, oxidative stress, cardiovascular, obesity, and aging. Curcumin is a promising and significant natural bioactive compound which has been shown to possess numerous pharmacological activities including anticancer, antidiabetic, cardiovascular protective, antiobesity, antimicrobial, wound healing, and nephroprotective activities. The molecule has also potential to protect from reproductive and respiratory disorders in association with its strong antioxidant potential. In near furture, curcumin is expected to be proven as a novel drug to treat and cure several human disorders such as carcinogenesis, inflammatory disorders, and oxidative stress-induced pathogenesis." - Trends in Food Science & Technology